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Learning More About Autoimmune Diseases: Antiphospholipid Syndrome (APS / APL)

Antiphospholipid Syndrome (APS / APL)

Antiphospholipid Syndrome (APS for short) is an autoimmune of the blood that causes blood clots to form in both the veins and arteries (known as thrombosis), and can cause serious complications. The blood clots can form anywhere in the body, but most commonly in the legs, kidneys and lungs. Any tissue, organ or part of the body can be affected. APS can be a primary condition or can be a secondary condition to another disorder, disease or condition such as Lupus. Some of the symptoms of APS include a purplish lace-like pattern of veins appearing through the skin (livedo reticularis), headaches and migraines.

APS can also cause serious complications with pregnancy, and may not even present until pregnancy. Some of the pregnancy related complications include miscarriage, stillbirth, pre-term delivery and severe preeclampsia. Some studies have also linked APS with the pregnancy complication called HELLP Syndrome as a trigger for APS.

There is no cure for APS, but treatment to control the symptoms and clotting is available.


Blood clots in legs
Blood clots in lungs
Blotchy, bluish rash that looks like lace that does not go away (livedo reticularis)
Chest pain
Difficulty concentrating
Memory loss
Multiple miscarriages
Partial blindness
Pregnancy complications such as preeclampsia., eclampsia and premature delivery
Skin lesions on the legs
Total vision loss
Ulcers on the feet
Unsteady balance and clumsiness

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